Toxicological Sciences

PROFILES IN TOXICOLOGY:

Robert Snyder

The International Symposium on Biological Reactive Intermediates
Toxicol. Sci. 2002 66: 173-175; doi:10.1093/toxsci/66.2.173 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

R. Mioduszewski, J. Manthei, R. Way, D. Burnett, B. Gaviola, W. Muse, S. Thomson, D. Sommerville, and R. Crosier

Interaction of Exposure Concentration and Duration in Determining Acute Toxic Effects of Sarin Vapor in Rats
Toxicol. Sci. 2002 66: 176-184; doi:10.1093/toxsci/66.2.176 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gary Ginsberg, Dale Hattis, Babasaheb Sonawane, Abel Russ, Prerna Banati, Mary Kozlak, Susan Smolenski, and Rob Goble

Evaluation of Child/Adult Pharmacokinetic Differences from a Database Derived from the Therapeutic Drug Literature
Toxicol. Sci. 2002 66: 185-200; doi:10.1093/toxsci/66.2.185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Alexander A. Constan, Brian A. Wong, Jeffrey I. Everitt, and Byron E. Butterworth

Chloroform Inhalation Exposure Conditions Necessary to Initiate Liver Toxicity in Female B6C3F1 Mice
Toxicol. Sci. 2002 66: 201-208; doi:10.1093/toxsci/66.2.201 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Scott E. Boley, Victoria A. Wong, John E. French, and Leslie Recio

p53 Heterozygosity Alters the mRNA Expression of p53 Target Genes in the Bone Marrow in Response to Inhaled Benzene
Toxicol. Sci. 2002 66: 209-215; doi:10.1093/toxsci/66.2.209 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Li You, Madhabananda Sar, Erika J. Bartolucci, Barry S. McIntyre, and Rajagopal Sriperumbudur

Modulation of Mammary Gland Development in Prepubertal Male Rats Exposed to Genistein and Methoxychlor
Toxicol. Sci. 2002 66: 216-225; doi:10.1093/toxsci/66.2.216 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Wim H. De Jong, François M. M. Van Och, Constance F. Den Hartog Jager, Sander W. Spiekstra, W. Slob, Rob J. Vandebriel, and Henk Van Loveren

Ranking of Allergenic Potency of Rubber Chemicals in a Modified Local Lymph Node Assay
Toxicol. Sci. 2002 66: 226-232; doi:10.1093/toxsci/66.2.226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Samantha L. Gadd, Gerry Hobbs, and Michael R. Miller

Acetaminophen-Induced Proliferation of Estrogen-Responsive Breast Cancer Cells Is Associated with Increases in c-myc RNA Expression and NF-B Activity
Toxicol. Sci. 2002 66: 233-243; doi:10.1093/toxsci/66.2.233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. A. Starkov and K. B. Wallace

Structural Determinants of Fluorochemical-Induced Mitochondrial Dysfunction
Toxicol. Sci. 2002 66: 244-252; doi:10.1093/toxsci/66.2.244 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Zhong-Yang Lu, Huaqing Gong, and Tsugio Amemiya

Aluminum Chloride Induces Retinal Changes in the Rat
Toxicol. Sci. 2002 66: 253-260; doi:10.1093/toxsci/66.2.253 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

D. L. Morgan, S. M. Chanda, H. C. Price, R. Fernando, J. Liu, E. Brambila, R. W. O'Connor, R. P. Beliles, and S. Barone, Jr.

Disposition of Inhaled Mercury Vapor in Pregnant Rats: Maternal Toxicity and Effects on Developmental Outcome
Toxicol. Sci. 2002 66: 261-273; doi:10.1093/toxsci/66.2.261 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Thomas Arnhold, Mohamed M. A. Elmazar, and Heinz Nau

Prevention of Vitamin A Teratogenesis by Phytol or Phytanic Acid Results from Reduced Metabolism of Retinol to the Teratogenic Metabolite, All-trans-retinoic Acid
Toxicol. Sci. 2002 66: 274-282; doi:10.1093/toxsci/66.2.274 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Seiichiroh Ohsako, Yuichi Miyabara, Motoharu Sakaue, Ryuta Ishimura, Masaki Kakeyama, Hiroyuki Izumi, Junzo Yonemoto, and Chiharu Tohyama

Developmental Stage-Specific Effects of Perinatal 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on Reproductive Organs of Male Rat Offspring
Toxicol. Sci. 2002 66: 283-292; doi:10.1093/toxsci/66.2.283 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Shin Yoshino, Hideyuki Hayashi, Shinji Taneda, Hirohisa Takano, Masaru Sagai, and Yoki Mori

Effect of Diesel Exhaust Particle Extracts on Induction of Oral Tolerance in Mice
Toxicol. Sci. 2002 66: 293-297; doi:10.1093/toxsci/66.2.293 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Wout Slob

Dose-Response Modeling of Continuous Endpoints
Toxicol. Sci. 2002 66: 298-312; doi:10.1093/toxsci/66.2.298 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wherly P. Hoffman, Daniel K. Ness, and Robert B. L. van Lier

Analysis of Rodent Growth Data in Toxicology Studies
Toxicol. Sci. 2002 66: 313-319; doi:10.1093/toxsci/66.2.313 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew S. Bogdanffy

Vinyl Acetate-Induced Intracellular Acidification: Implications for Risk Assessment
Toxicol. Sci. 2002 66: 320-326; doi:10.1093/toxsci/66.2.320 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Gregory A. Wellenius, Paulo H. N. Saldiva, Joao R. F. Batalha, G. G. Krishna Murthy, Brent A. Coull, Richard L. Verrier, and John J. Godleski

Electrocardiographic Changes during Exposure to Residual Oil Fly Ash (ROFA) Particles in a Rat Model of Myocardial Infarction
Toxicol. Sci. 2002 66: 327-335; doi:10.1093/toxsci/66.2.327 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kiran Kodithala, A. J. Hopfinger, Edward D. Thompson, and Michael K. Robinson

Prediction of Skin Irritation from Organic Chemicals Using Membrane-Interaction QSAR Analysis
Toxicol. Sci. 2002 66: 336-346; doi:10.1093/toxsci/66.2.336 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vincent V. Rogers, Mark Wickstrom, Karsten Liber, and Michael D. MacKinnon

Acute and Subchronic Mammalian Toxicity of Naphthenic Acids from Oil Sands Tailings
Toxicol. Sci. 2002 66: 347-355; doi:10.1093/toxsci/66.2.347 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Ian C. Munro, Lois A. Haighton, Jason J. Hlywka, Barry S. Lynch, John Doull, and Robert Kroes

Carcinogenicity Bioassay of Bisphenol A
Toxicol. Sci. 2002 66: 356; doi:10.1093/toxsci/66.2.356 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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